Efficacy of Testosterone Therapy Delivered by Pellet Implant

ment (HT) in a group of women with diabetes mellitus type II (DM) on menopause compared with nondiabetic patients. Methods: The analysis included 163 women 94 without HT (22 DM), and 69 with HT (16 DM), followed-up for two years. The descriptive data were socio-demographic, BMI, dietary habits, alcohol consumption, smoking, menopause symptoms before and after HT, with or without HT. Lab tests were assessed every 6 months combined with a physical exam. HT was estradiol transdermal with dydrogesteron (12 days monthly). Results: Symptoms were similar for DM and nonDM, but in DM patients the urogenital problems were significant higher. The BMI decreased, significantly under HT in the DM vs controls. Trigliceridemia decreased significantly in the DM group. The results were maintained till the end of the 2 years followup. HDL-Cholesterol increased at 6 month of treatment in HT, mostly for the DM patients. LDL-Cholesterol and total Cholesterol levels were lower in the HT patients. Glycemia levels decreased under HT in DM patients, and during the follow-up no patient with DM under HT changed on insulin therapy. QoL significant improved under HT for DM and nonDM and maintained during follow-up. Conclusions: HT has positive effects on lipid and glycemic metabolism, mostly for DM patients. Transdermal HT had beneficial effects in DM. The key points of the good results of HT in menopause are strict controlled indications, follow-up, individualization of the dose and natural HT.